role of Zizyphus spina christi extract and bifidobacterium as a biotherapeutic agent in prevention of osteoporotic postmenopausal women

ABSTRACT

The objective of this study was to evaluate the efficacy of the consumption of bioactive yogurt [probiotic] in combination with Nabq fruit [Zizyphus Spina Christi, ZSC] extract as bioavailable isoflavone in osteoporotic postmenopausal women..Analysis by HPLC of ZSC extract showed that the main constituents of this extract exhibited a chromatographic profile corresponding to rutin, quercereterin, quercin, kamaferol, chlorogenic and ferrulic. The study was conducted on 25 postmenopausal women.Our results revealed that the level of serum osteocalcin [OC] was significantly decreased on daily consumption of yogurt fortified with Bifidobacteria in combination with ZSC extract. This indicated down-regulation of bone turn-over. The level of serum parathyroid hormone [PTH] and ionized calcium [Ca2+] were also reduced significantly. This study proposed that phytoestrogens efficacy of ZSC extract in combination with probiotics prevent bone mineral loss due to ovarian estrogen deficiency possibly by promoting intestinal calcium absorption and enhancing antiresorptive agent in osteoporotic postmenopausal women