Chemical and biological investigation of kigelia pinnata

ABSTRACT

The crude ethanolic extract of the stem bark of Kigelia pinnata was evaluated for its antioxidant, cytotoxic and antinociceptive activities. The antioxidant property of the ethanol extract of Kigelia pinnata was assessed by 1, l-diphenyl-2-picryl hydrazyl [DPPH] free radical scavenging assay. The extract showed potential antioxidant activity [IC[50] about 110 micro g/ml], which was comparable to standard drug ascorbic acid [IC [50] at about 3.16 micro g/ml]. Brine Shrimp lethality bioassay indicated its cytotoxic property [LC[50] 100 micro g/ml]. Moreover, it produced significant [P < 0.001] writhing inhibition in acetic acid induced writhing in mice at the dose of 250 and 500 mg/kg body weight respectively, which was comparable to the standard drug diclofenac sodium. The results tend to suggest the antioxidant, cytotoxic and antinociceptive activities of the crude ethanolic extract of Kigelia pinnata