Some aspects of drug interaction

ABSTRACT

One hundred and twenty adult rats were used in this study. They were divided into 6 groups each of twenty. The first group was used as control, the second group was treated with 5 fluoro uracil for 4 weeks, the third group was treated with 5 fluoro uracil then exposed to sub anaesthetic doses of halothane for the last 3 weeks. The fourth group was treated with 5-fluoro uracil and exposed to sub-anaesthetic doses of isoflurane, the fifth group and the sixth groups were exposed to sub anaesthetic doses of halothane and isoflurane sub-sequently. There was a reduction in the antibody titres in the sera of rats belonging to groups 2, 3 and 5, while those rats belonging to groups 4 and 6 their titres resemble the normal at the 7[th] day post injection with bovine serum albumin [BSA]. There was anaemia in rats belonging to groups 2, 3 and 4. Leucopenia with lymphopenia was seen in rats belonging to groups 2, 3 and 5 and slight leucocytosis with lympho-cytosis was demonstrated in the blood of rats belonging to group 6. The histopathological changes of lungs, spleen and foot pads of all group were investigated and discussed