Synthesis and evaluation of some 2-, 4-, and 2, 4distributed-6-methyl pyrimidine derivatives for antimicrobial activity

ABSTRACT

The reaction of 2-amino-4-chloro-, 4-amino-2-chloro-, and 2,4- dichloro-6-methyl-pyrimidines with primary aromatic amines under acidic conditions is presented. 2-, and 4-w substituted thio- ureide-6- methylpyrimidines were synthesized via the reaction of 2-amino-,and 4- amino-6-methylpyrimidine derivatives with aryl- isothiocyanates Six compounds were evaluated for their antimicrobial activity and most of them showed a moderate activity against B subtilis, E. coli, and A. Niger