Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs
Iranian Journal of Veterinary Research. 2008; 9 (3): 266-270
in English
| IMEMR
| ID: emr-87314
ABSTRACT
Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride [50 mg/kg] to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non-compartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg. min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Spectrometry, Fluorescence
/
Tetracycline
/
Dogs
/
Injections, Intravenous
Limits:
Animals
Language:
English
Journal:
Iran. J. Vet. Res.
Year:
2008
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