Triglyceride profile in dyslipidemia of type 2 diabetes mellitus
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2008; 18 (5): 270-273
in English
| IMEMR
| ID: emr-87575
ABSTRACT
To evaluate ratios of serum triglycerides and cholesterol levels which may indicate postprandial lipid handling and to assess their role as prospective markers of dyslipidaemia in type 2 diabetes mellitus. Comparative, observational study. Bismillah Taqee Hospital, Karachi from July 2002 till December 2003. The study comprised 160 subjects, including 83 known type 2 diabetics [45 males, 38 females] and 77 age-matched controls [45 males, 32 females]. Fasting blood samples were analysed for serum triglycerides and total cholesterol, using automated chemistry analyzer. HDL-C was determined by precipitation method and LDL-C and VLDL-C were estimated by Friedewalds formula. LDL/HDL ratio and TG/HDL ratios were also calculated. The mean values for male and female diabetics were compared with that for the male and female non-diabetics respectively and tested for significance by paired t-test. Serum triglycerides and VLDL were raised in both male and female diabetics. No significant differences were observed in levels of serum total cholesterol, LDL, HDL and the LDL/HDL ratio. The mean value of the TG/HDL ratio for male diabetics was higher than that for the male non-diabetics [p=0.39]. A statistically significant difference was found in the TG/HDL ratios for the female diabetics and non-diabetics [p < 0.05]. In this study, type 2 diabetics showed marked hypertriglyceridaemia and raised TG/HDL ratio. The dyslipidaemia of diabetes predisposes to development of coronary heart disease and, therefore, evaluation of the TGHDL ratio may provide a good tool to monitor and manage the lipid abnormalities in diabetics
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Triglycerides
/
Cholesterol, VLDL
/
Cholesterol
/
Coronary Disease
/
Dyslipidemias
/
Cholesterol, HDL
/
Cholesterol, LDL
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Coll. Physicians Surg. Pak.
Year:
2008
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