study of plasma concentration [Zinc and Copper] and their relation in rheumatoid arthritis ptarients in comparison to control group

ABSTRACT

The role of trace elements [Cu, Zn] in chronic inflammatory states has provided interest, as many of them are co-factors in metabolic processes, involving arthricular tissues and immune system function. The purpose of the current study was to evaluate zinc and copper plasma concentration in rheumatoid arthritis [RA] patients, who were referred to the Sari Outpatient Clinics and were compared with control group. We studied plasma concentrations of Zn and Cu in 40 patients with RA and compared them with sex and age matched of healthy subjects [N=40]. Plasma Cu and Zn concentrations were determined by an analysis of 100 Perkin Elmer model flame atomic absorption spectrometer [FAAS]. The plasma Zn concentration in the patient group was statistically lower than control group. The plasma copper was not statistically different in comparison with control group. There was no correlation between Cu and Zn concentration in patient group. In contrast to Cu, there was a significantly positive correlation between Zn and Zn/Cu ratio. However, the decrease of Zn/Cu is more influenced by decreasing the Zn concentration. It appears the decrease of Zn plasma concentration in patients [comparison with control group] is more important than the differences in plasma Cu concentration, but the use of Zn supplement for RA patients needs more investigation