Dose related effect of systemic antibiotics in prevention of postoperative intra-abdominal adhesion formation in experimental animals
Journal of the Egyptian Society of Parasitology. 2008; 38 (3): 813-822
in English
| IMEMR
| ID: emr-88283
ABSTRACT
Sixty hamsters weighing 100-120 g were randomly assigned to 2 equal groups. GI was injected intramuscularly with saline, half an hour preoperatively as control, and GII was injected with 50 mg/kg Cefepime HC1 and 7.5 mg/kg Metronidazole. After a midline lapparo-tomy, abdominal adhesions were induced in GI and GII Post-operration, animals in GI was divided according to the numbers of intramuscular saline injections into 2 subgroups. GIa[15] in which animals were injected every 12 hours for 2 doses and GIb [15] where animals were injected every 12 hours for 5 days. Similarly, the antibiotic group was subdivided into GIIa [15] and GIIb [15]. On the 14[th] day, the hamsters were sacrificed and the adhesion score was determined. The 5 day antibiotics course revealed significant reduction in incidence [P < 0.01], extent [P < 0.001] and severity [P < 0.01] of the postoperative peritoneal adhesions, while the short course failed
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Tissue Adhesions
/
Cricetinae
/
Antibiotic Prophylaxis
/
Models, Animal
/
Abdomen
/
Infusions, Parenteral
/
Anti-Bacterial Agents
Limits:
Animals
Language:
English
Journal:
J. Egypt. Soc. Parasitol.
Year:
2008
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