Correlation between leptin hormone levels and bone mineral density in hepatitis C patients with chronic liver disease
Medical Journal of Cairo University [The]. 2008; 76 (1): 63-66
in English
| IMEMR
| ID: emr-88806
ABSTRACT
There is accumulating evidence that leptin has a pleiotropic role in hematopoiesis, immune response, fibro-genesis, and hepatocarcinogenesis. The aim of this study was to determine the correlation between leptin levels and bone mineral density in HCV chronic liver disease patients. A medical history to retrieve information about health status, current medications and history of viral or toxic hepatitis; a physical examinations including height and weight; a fasting blood draw for the determination of liver profile and leptin. BMD values were measured by dual-energy X-ray absorptiometry [DEXA] at the L2-L4 lumbar spine and femoral neck. Fasting leptin was highly increased in HCV CLD patients with osteopenia than HCV CLD patients with normal hone mineral density [p<0.05]. Leptin showed a significant negative correlation with bone mineral density [BMD] in HCV CLD patients [r=-0.191, p=0.039] and significant positive correlation with age [r=0.331, p=0.041]. Serum concentrations of leptin is positively correlated in chronic liver disease patients with age and negatively correlated with BMD especially in patients with hepatitis C infection
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Absorptiometry, Photon
/
Bone Density
/
Chronic Disease
/
Cross-Sectional Studies
/
Hepatitis C
/
Liver Diseases
/
Liver Function Tests
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. J. Cairo Univ.
Year:
2008
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