Medical Journal of Cairo University [The]. 2008; 76 (4): 743-753
in English
| IMEMR
| ID: emr-88899
ABSTRACT
There is still uncertainty about angiogenesis as a prognostic factor in breast cancer. To evaluate the prognostic value of microvascular density [MVD] in breast carcinoma and soluble vascular cell adhesion molecule-1 [sVCAM-1], leptin, estradiol and total testosterone as angiogenic markers. Efficacy of shark care drug was assessed by patient's overall survival. 30 premenopausal breast cancer patients [group II] and 15 controls [group I]. Group II was subgrouped into 15 patients receiving chemotherapy alone [IIA] and 15 patients receiving chemotherapy + shark care drug [IIB]. After modified radical mastectomy, microvessels were counted by staining tissues for factor VIII. For surrogate markers, enzyme-linked immunosorbant assay or radiommunoassay kits were used. A high MVD was found only in areas of carcinoma. MVD and sVCAM-1 correlated significantly with each other and with lymph node involvement. After the follow-up, all subgroup IIB patients were alive compared to 66.6% of subgroup IIA [p=0.02]. A high MVD may be a poor prognostic marker of breast carcinoma and a target for antiangiogenic therapy sVCAM-1 is useful for diagnosis and for monitoring response to therapy. Chemotherapy + shark care drug seem to ameliorate the outcome of these patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Testosterone
/
Immunohistochemistry
/
Mastectomy, Radical
/
Premenopause
/
Vascular Cell Adhesion Molecule-1
/
Leptin
/
Angiogenesis Inhibitors
/
Estradiol
/
Neovascularization, Pathologic
Limits:
Female
/
Humans
Language:
English
Journal:
Med. J. Cairo Univ.
Year:
2008
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