Behavioral effects of l-[m-chlorophenyl] piperazine [m-CPP] in a rat model of tardive dyskinesia
Pakistan Journal of Pharmaceutical Sciences. 2008; 21 (3): 262-268
in English
| IMEMR
| ID: emr-89423
ABSTRACT
The present study was designed to monitor the responsiveness of 5-hydroxy tryptamine [5-HT]-2C receptor in rats treated with haloperidol exhibiting tardive dyskinesia [TD]. Results show that haloperidol injected at a dose of 1 mg/kg twice a day for two weeks elicited vacuous chewing movements [VCMs]. Which increased in a time dependent manner following the drug administration for 3-5 weeks. The behavioral effects of 1-[m-chlorophenyl]piperazine [m-CPP] a 5-HT-2C and 5-HT-1B agonist were monitored 2 days after 5 weeks of saline or haloperidol administration. The results show that hypophagic as well as anxiogenic-like effects of m-CPP are greater in repeated haloperidol than repeated saline injected animals, while hypolocomotive effects of m-CPP are not different in repeated saline and haloperidol injected animals. Results are discussed in the context of role of 5-HT-2C receptors in the regulation of the activity of dopaminergic neuron and its possible impact on elicitation of TD
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Piperazines
/
Rats, Wistar
/
Receptor, Serotonin, 5-HT2C
/
Dyskinesia, Drug-Induced
/
Haloperidol
Limits:
Animals
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2008
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