Anti inflammatory activity of indanyltetrazole derivatives

A number of indanyl tetrazolederivatives namely 5-[6'-chloroindan-1'-yl]tetrazole [CIT], 5-[6'-bromoindan-1'-yl]tetrazole [BIT], 5-[6'-chloroindan-1'-yl]methyltetrazole [CIMT], 5-[6'-bromoindan-1'-yl]methyl-tetrazole [BIMT] were evaluated for the anti-inflammatory activity in carragennan induced rat paw edema in Swiss albino Wister rats for 24-hour period at the dose of 100 mg/kg of body weight by intraperitoneal route where phenylbutazone [PBZ] was used as the standard. All of these compounds exhibited inhibition on rat paw edema with peak actions observed following 3 hours after administration. Moreover, compounds CIMT and BIMT were further evaluated at dose of 50 mg/kg of body weight. Among the compounds, CIMT showed higher activity than others and was very close to standard phenylbutazone