Relationship between the serologic status of Helicobacter pylori with the presence of unstable angina

ABSTRACT

To determine whether unstable angina is co-related to seropositivity to chronic Helicobacter pylori [HP] infection. It is a case control, descriptive study conducted at CCU in Razi Hospital in Ahwaz a city southwest Iran, from 2004 to 2005.We measured serum HP- IgG levels of participants in CCU in a hospital. Blood samples were drawn during study period from 96 patients [mean age 56 years] with Unstable Angina [UA] according to American Heart Association criteria and from 96 participants free of cardiovascular disease [mean age 58 years] and stored at "20°C. Serology results were studied in relation to UA. Using chi squared test, odds ratios [OR] and 95% confidence intervals [CI] were calculated, adjusting for age, gender, and established risk factors. Seventy nine [82.3%] of patients with unstable angina and 55[61.1%] in the control group presented a positive anti HP-IgG. Odds ratio was 3 with 95% CI 1.9 to 4.3. There was significant relation between HP-IgG positivity and unstable angina [P<0.001].There was no sex and age significant difference in HP-IgG positivity in patients and controls [P>0.05]. Our study revealed relationship between seropositivity of HP-IgG and unstable angina