Age as a predictor of assisted reproductive techniques outcome

ABSTRACT

This study evaluated the effect of age on ovarian response to gonadotropin stimulation and the success of IVF and ICSI cycles. In this retrospective analytic study, 280 women undergoing first IVF and ICSI cycles were collected. Patients were divided in three groups <35 years old, 35- 39 years and e"40 years old. Stimulation protocol for all patients was Long standard protocol. There were significant decrease in the number of follicles, oocytes retrieved and embryos obtained with increasing age [p<0.05]. Fertilization rate did not differ significantly with increasing age [P>0.05]. Clinical pregnancy rate were 21.8% in patients < 35, 13.2% in patients 35-39 and 5.9% in e"40 [p= 0.157] and Live birth rate were 14.2% in patients <35,7.9% in 35-39 and 5.9% in e"40 years old. [p= 0.50]. Clinical pregnancy rate and live birth rate diminished with increasing age