Pakistan Journal of Medical Sciences. 2008; 24 (4): 485-490
in English
| IMEMR
| ID: emr-89562
ABSTRACT
To compare the effects of the ACE inhibitor captopril with the calcium channel blocker amlodipine on serum CRP concentrations in hypertensive type 2 diabetic patients. This is a case control study conducted in Al-Wafa Diabetic Center in Mosul. Serum CRP concentrations were measured in two groups of hypertensive type 2 diabetic patients before and after drug administration [group 1 on captopril therapy, group two on amlodipine therapy]. A significant reduction of serum CRP level was demonstrated after treatment with captopril but not with amlodipine. Mean CRP concentration of the control group was statistically lower than those of captopril and amlodipine groups. The present study showed that hypertensive type 2 diabetic patients are associated with increased level of CRP and therapy with captopril but not amlodipine significantly reduced CRP, suggesting a possible anti-inflammatory action of captopril in addition to its BP lowering effects thus captopril may be regarded as the drug of choice in the treatment of BP in diabetic hypertensive patients
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
C-Reactive Protein
/
Angiotensin-Converting Enzyme Inhibitors
/
Calcium Channel Blockers
/
Captopril
/
Case-Control Studies
/
Amlodipine
/
Diabetes Mellitus, Type 2
/
Hypertelorism
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Pak. J. Med. Sci.
Year:
2008
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