Pakistan Journal of Medical Sciences. 2008; 24 (4): 531-536
in English
| IMEMR
| ID: emr-89571
ABSTRACT
This study determines the expression of latent membrane protein-1 [LMP- 1] in lymph nodes of patients with classic Hodgkin lymphoma [cHL] and its role in patients' survival. Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival [DFS] was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy. We investigated the expression of LMP-1 in outcome of patients with cHL. LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight [25.5%] patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% [P= 0.005]. Patients with EBV-positive tumors had fewer DFS [22.6 vs. 25.9 mo], but the difference was not statistically significant [p=0.06]. Although in our study there is no relationship between age and LMP-1 expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Hodgkin Disease
/
Immunohistochemistry
/
Survival Analysis
/
Viral Matrix Proteins
/
Cross-Sectional Studies
/
Disease-Free Survival
/
Epstein-Barr Virus Infections
/
Lymph Nodes
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Pak. J. Med. Sci.
Year:
2008
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