evaluation for isolated unexplained optic atrophy: implications for Saudi Arabia

ABSTRACT

To describe the evaluation of isolated optic atrophy based upon the individual clinical presentation, history and exam of the patient and a directed work up for disorders which are endemic to the patient population of interest. Review of literature and expert opinion. The evaluation of optic atrophy can be difficult and can lead to many expensive or unnecessary tests. The majority of patients with optic atrophy have historical or examination findings that allow the clinician to make an etiologic diagnosis or provide specific guidance for a focused laboratory or radiographic evaluation. Neuro-imaging, preferably cranial magnetic resonance imaging [MRI] with and without contrast and including orbital fat suppression is generally considered the first line evaluation for all patients with unexplained optic atrophy. Directed laboratory or other radiographic testing should be individualized based upon the prevalence of specific disorders in the patient population of interest