Isolation and identification of a new homoisoflavan with potent antioxidant activity from commelina elegans
SPJ-Saudi Pharmaceutical Journal. 2008; 16 (1): 25-32
in English
| IMEMR
| ID: emr-90365
ABSTRACT
Potent antioxidative compounds have been isolated from the ethyl acetate extract of Commelina elegans, Commelinaceae, using a repeated column chromatography. On the basis of spectral analyses, the compounds were identified as brazilin, brazilein and the new homoisoflavan-3, 7, 9, 3', 4'-ol [4-4] dimer with X- and Y-conformers. The compounds inhibited both enzymatic lipid peroxidation using rat liver microsomes and mitochondria and non-enzymatic reactions. The compounds completely protected the activities of the mitochondrial enzymes NADH- and succinate-cytochrome c reductase. Furthermore, the radical scavenging activity on enzymatically and non-enzymatically generated superoxide anion was investigated. Electron spin resonance using the spin trapping method suggested that the compounds have potent superoxide anion scavenging activities
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Benzopyrans
/
Plant Extracts
/
Free Radical Scavengers
/
Phytotherapy
/
Antioxidants
Language:
English
Journal:
Saudi Pharm. J.
Year:
2008
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