Antidiabetic and antioxidant activity of Jasonia Montana extract in streptozotocin-induced diabetic rats

ABSTRACT

The aim of the present study is to investigate the antioxidant activities of the ethanolic and aqueous extracts of the aerial parts of J. Montana in streptozotocin- induced diabetic rats. Oral administration of both the aerial parts extracts at a concentration of 150 mg/kg b.w daily for 30 days showed a significant decrease in fasting blood glucose, hepatic and renal thiobarbituric acid reactive substances and hydroperoxides. The treatment also resulted in a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-stransferase in the liver and kidney of diabetic rats. The results clearly suggest that the aerial parts of J. Montana treated group may effectively normalize the impaired antioxidant status in Streptozotocin induced diabetes than the glibenclamide-treated groups. The extract exerted rapid protective effects against lipid peroxidation by scavenging of free radicals by reducing the risk of diabetic complications. The effect was more pronounced in ethanolic extract compared to aqueous extract