Assessment of anti-inflamatory and analgesic activities on the co-administration of acetyl salicytic acid and diclofenac sodium [voltaren] in adjuvent-arthritic rats

ABSTRACT

The effects of interaction between acetyl salicylic acid [300 mg/ kgm/day orally for 2 weeks] and diclofenac [25 mg/kgm/day orally for 2 weeks] were studied in albino rate rendered arthritic by intradermal injection of mycobacterium butyricum. The fluorimetric estimation of plasma cortisol level showed significant elevation following acetyl salicylic acid administration and also following combined diclofenac and acetyl salicylic acid administration but to a less extent, while ibuprofen alone failed to produce any significant change. Analgesic activity was assessed by analgesymeter test. Acetyl salicylic acid and Diclofenac given separately or concurrently produced a highly significant analgesic action which did not differ statistically in various groups. Anti-inflammatory activity was assessed by the paw oedema test, the anti-inflammatory action of diclofenac was statistically more marked than that of acetyl salicylic acid, but was more or less similar to the effect of concurrent drug administration. It could be concluded that the analgesic action of combined acetyl salicylic acid and diclofenac administration was not superior to either drug when given alone, and the anti-inflammatory action of combined aministration did not differ from that of diclofenac alone, thus one could suggest that, this form of combined drug therapy has no advantage over ibuprofen alone