Levels of serum intercellular and vascular adhesion molecules in insulin dependent diabetic nephropathy patients

ABSTRACT

The study evaluated the possible significant role of soluble intercellular and vascular adhesion molecule- 1 [sICAM-1 and sVCAM-1], sE-selectin and interluekin-l beta in development nephropathy in patients with insulin dependent diabetes mellitus [IDDM]. This study included 60 patients with type 1 diabetes mellitus [IDDM], together with 20 healthy control subjects. Patients were divided into 3 groups according to the onset of disease. All studied groups were subjected to clinical and laboratory evaluation of serum soluble sIC AM- 1, sVCAM-1, sE-selectin, IL-l beta in association with microalbumin, and CRP. A highly significant elevation of soluble adhesion molecules [sICAM-1, sVCAM -1 and sE-selectin] and microalbuminuria were observed in patients with IDDM, while there was no significance difference in ILl-beta in the same patients. Our findings may have clinical implications, since they may indicate that, these adhesion molecules are known as very strong marker for renal complications and the circulating forms of these adhesion molecules have been associated with clinical vascular events and all-cause mortality in the renal population