Autologous bone marrow-derived stem cell therapy in patients with Buerger's disease
Endovascular Journal. 2009; 2 (1): 18-22
in English
| IMEMR
| ID: emr-91060
ABSTRACT
Patients suffering from Thrornboangiitis Obliterans [TAO] or Buerger's disease have endothelial cell dysfunction and the severity of the disease lies in the need for amputation in more than a quarter of all sufferers. The aim of present study was to determine whether granulocyte colony-stimulating factor mobilized autologous bone-marrow derived mononuclear cells transplantation improves endothelial dysfunction in these patients. Circulating mononuclear cells containing endothelial progenitor cells were obtained from patients following bone-marrow mobilization with granulocyte colony stimulating factor. Mononuclear cells and CD34+ cells were enumerated prior to intramuscular injection into the affected limbs. In this pilot study, autologous bone-marrow derived mononuclear cell therapy collected from peripheral blood following granulocytes colony stimulating factor [G-CSF] mobilization was effective, safe and resulted in sustained clinical results for patients with severe peripheral occlusive arterial diseases
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Thromboangiitis Obliterans
/
Thrombosis
/
Transplantation, Autologous
/
Bone Marrow
/
Granulocyte Colony-Stimulating Factor
/
Stem Cell Transplantation
/
Endothelial Cells
/
Angiogenesis Inducing Agents
/
Amputation, Surgical
Limits:
Humans
/
Male
Language:
English
Journal:
Endovascular J.
Year:
2009
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