Histological study of the effect of hypervitaminous D on some organs of albino rat

ABSTRACT

Adult male albino rats were injected with variable doses of vitamin [D] for different periods sections from their kidneys and aortae were then stained with HX and E and Van Gieson's stain. Marked damage of the kidney was observed in the form of atrophy of the capillary tuft, thickening of Bowman's capsules, irregular dilatation of the renal tubules with areas of haemorrhage and cellular infiltration of the intestinal tissue with deposition of acidophilic and basophilic materials. Deformity of the walls of the aorta was noticed with destruction of its elastic lamellae and deposition of basophilic materials. High toxic doses of vitamin [D] led to distortion of the wall with aneurismal formation and appearance of hyaline cartilage like tissues inside its wall