[Comparing the effects of two training methods of aerobic and anaerobic on some pre-inflammatory cytokines in adult male rats]

ABSTRACT

Data available reports that the novel biomarkers of cardiovascular diseases have more sensitivity and accuracy in anticipating cardiovascular disease. Hence, considering the significant role of physical activity in decreasing and preventing these diseases, determining the type of physical activity, its duration and intensity, and appropriate pattern significantly promotes the individual's health. In this study, effects of two training methods, the aerobic and anaerobic, on some pre-inflammatory cytokines in adult male rats were compared. In this experiment, 54 male wistar rats [3 months], were kept in a controlled condition, randomly divided into three groups, the control, aerobic and anaerobic groups. The training program was conducted for a period of 12 weeks - 3 sessions per week, specified durations and intensity. To assess the influence of one session of an aerobic and anaerobic, training program, following the program, the first blood sample was taken. After the 24th and 36th sessions, the second and the third blood samples were obtained. Blood samplings were done after 14 hours of fasting and 24 hours after the final training session. Data were analyzed with Kolmogrov-Smirnov, One Way ANOVA, Repeated Measurement and the LSD post hoc tests, at the level of alpha training causes a significant decrease in quantities of slCAM-1 [p<0. 001], inflammatory mediators of IL-1beta [p<0. 01], and TNF-alpha [p<0. 05], whereas anaerobic training leads to a significant increase in quantities of slCAM-1[p<0. 01], IL-1beta [p<0. 05] and TNF-alpha [p<0. 05]. The results of this study show that the regular aerobic training [55-85% Vo2max] causes a significant decrease in novel biomarkers of cardiovascular diseases, whereas intensive anaerobic training [100 and over 100%Vo2max] causes a significant increase in these, and exposes the body to the risk of inflammatory impairment. Therefore, it is possible that decrease in the novel anticipating factors of cardiovascular diseases after regular aerobic training could be due to reduction of the atherogenesis process, whereas anaerobic training could have the opposite effect