Effect of Fas-670 A/G gene polymorphism on corneal allograft endothelial rejection
IJI-Iranian Journal of Immunology. 2009; 6 (1): 28-32
in English
| IMEMR
| ID: emr-91224
ABSTRACT
Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction [ASO-PCR] techniques. There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode [p=0.35]. Moreover, the relationship between this polymorphism and rejection episode outcome [transplant recovery vs failure] was not statistically significant [p=0.13]. The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polymorphism, Genetic
/
Polymerase Chain Reaction
/
Cross-Sectional Studies
/
Fas Ligand Protein
/
Graft Rejection
Type of study:
Prevalence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Iran. J. Immunol.
Year:
2009
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