Effect of specific chemotherapy on serum enzymes in patients with schistosomiasis

ABSTRACT

The morbidity of sehistosomia sis reflected on the electrophoretic and enzymatic liver functions was studied in patients with either S. mansoni or mixed infection. The reflection of specific chemotherapy [praziquantel] on the morbidity of the disease was studied 48 hours, one, two, and four weeks after treatment. S. mansoni infection produced a significant decrease in the albumin level with corresponding increase in the gamma-globulin fraction, alkaline phosphatase and transaminases. In mixed infection the pattern of changes was nearly that of single S. mansoni infection apart from a significant increase in the bilirubin level. Praziquantel normalized albumin globulin changes in patients with mixed infection, no statistically significant changes were recorded throughout the period of observation