Chlamydia pneumoniae seropositivity associated with atherothrombotic cerebrovascular infarction?

ABSTRACT

Several studies suggested that Chlamydia pneumoniae [CP] infection may be a risk factor for cerebrovascular disease. Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction [ACI] in Iranian patients. Forty-five patients admitted with ACI, and 45 control without ACI were enrolled in this case-control study. Using an enzyme-linked immunosorbed assay kit [ELISA], the presence of CP-immunoglobulin [CP-IgG] in studied patient's sera was determined. The seroprevalence of CP-IgG was 35[77.7%] in the ACI group [mean age = 73.3 years] and 29[64.4%] in the control group [mean age = 70.1 years] [P > 0.05]. There was no difference in sex, age, hypertension, smoking, hyperlipidemia, diabetes and obesity between cases and control groups [P > 0.05]. No association was observed between CP seropositivity and ACI [OR 1.95 [95% CI, 0.081-2.03], P = 0.16]. Our finding suggests that there is no association between ACI and positive CP-IgG in Iranian patients