effect of aqueous extracts of purtulaca oleracea on withdrawal syndrome in mice

ABSTRACT

Purtulaca pleracea [PO] overgrows in the different parts of Iran. In previous studies, the extract of P.O showed antinociceptive, anxiolytic and anti inflammation effects in Mice and rats. This study was designed to evaluate different doses of the aqueous extracts of PO on withdrawal syndrome on mice. In this study, 40 male albino mice [25-30 gr] were used. Morphine was used to produce drug dependency by Marshall Method [10 doses of drug in four days]. Different doses of the extract. [25, 50, 75 mg/kg IP] were injected to the separated groups and saline [10 ml/kg-ip] were injected to the one control group 30 min before of noloxone 2 mg/kg. The number of Jumping and amount of weight losses were used for assessment of classic withdrawal syndrome sign. The results indicated that the extract of PO significantly decreased the number of Jumping [p= 0.000] and also weight losses in 25 mg doses of extract [dose-dependent] in mice [p=0.045] It is concluded that the aqueous extract of PO may be play an important role on the modulation of withdrawal syndrome in mice