[Association between anti- beta 2GP1 autoantibody with Acute Coronary Syndrome]

ABSTRACT

Atherosclerosis is a chronic autoimmune inflammatory disease that remains the most common cause of death in the globe. This affects the vascular wall and leads to coronary artery diseases. Several studies have evaluated the association between auto-antibodies and cardiovascular disease. One of the candidate autoantigens is the Beta 2-glycoprotein I [beta 2GPI]. Determining risk factor of the coronary heart diseases is of huge significance, so we carried out the comparative study of Anti- beta 2GP1 autoantibody level in patients with Acute Coronary Syndrome and healthy controls in Gorgan, Iran. A case-control, study was conducted on 179 subjects in 2007 in whom 79 subjects were healthy [Control group] and 100 subjects had coronary artery disease [Case group]. A questionnaire was filled by all subjects. Blood and serum samples were assessed by commercial ELISA tests measuring IgM and IgG auto-antibodies to beta 2GP1 antigen. Data were analyzed using student t-test and Fisher test. The positivity of IgG and IgM isotypes for anti- beta 2-GPI antibodies in serum of the cases were%68.6 and%43, respectively. Our results also indicated that frequency of IgG and IgM autoanti-beta2-GPI isotypes in serum of the controls were%48.1 and%2.5, respectively. The results from the serum of the subjects showed that IgG-antibody against beta 2GPI was found in%50 of the female cases and%73.2 of the male cases [P<0.01]. On the other hand, this values were%48.5 of females and%47.8 of males in control group [P<0.05]. Our finding shows that there is a relation between serum levels of IgG-antibodies against beta 2GP and coronary artery diseases