[Evaluating the correlation between HbA1C and growth parameters, lipid profile in children and adolescents with type 1 diabetes]

ABSTRACT

Type 1 diabetes is the most common endocrine disorder in children. The disease is associated with a variety of complications including growth abnormalities. The aim of this study was to evaluate the role of diabetes and blood sugar control on physical growth [height and weight], growth parameters and lipid profile. This descriptive cross- sectional study took place from July 2006 to July 2007. A total of 154 children and adolescents with diabetes type 1, evaluated for their growth parameters, lipid profile, and its correlation with duration of diabetes and mean HbA[1C]. The mean age of diabetes diagnosis recorded 6.2 +/- 3.1 year. The mean height growth velocity was 4.8 +/- 1.48 cm and the mean weight growth velocity 3 +/- 1.5 kg in one year. In the first group with HbA1c growth velocities were 4.8 +/- 1.3 cm and 3.03 +/- 1.6 kg in a year respectively. In the second group with HbA1C >/= 8 [mean +/- 1SD], yearly height and weight growth velocities measured 3.2 +/- 1.22 cm and 3.03 +/- 1.2 kg in turn. Moreover, in the first group TC, LDL, HDL and TG were 163.1 +/- 34 mg/dl, 109.3 +/- 22 mg/dl, 49.5 +/- 1 mg/dl, 116.3 +/- 55 mg/dl and in the second group 172.6 +/- 46 mg/dl, 122.4 +/- 80 mg/dl, 48.5 +/- 1 mg/dl, 153.3 +/- 1.5 mg/dl in the order mentioned. In the group with disease duration less than 5 years, height and weight growth velocities were 5.7 +/- 1.4 cm and 3.3 +/- 1.6 kg and in group with disease duration more than 5 years, height and weight velocities reported 3.74 +/- 1.2 cm and 3.3 +/- 1.2 kg annually respectively. According to this study, there was no correlation between the mean of height, weight growth velocities and metabolic control in both groups. However, the height growth disorder and increase in the level of TG were correlated with the duration of disease. Also, lipid profile [dislipidemia] was associated with the lack of metabolic control