Prophylactic antiemetic effects of midazolam, dexamethasone, and its combination after middle ear surgery
Saudi Medical Journal. 2009; 30 (4): 504-508
in English
| IMEMR
| ID: emr-92689
ABSTRACT
To evaluate and compare the efficacy of the combination of midazolam and dexamethasone, with midazolam and dexamethasone alone, for the prevention of postoperative nausea and vomiting [PONV] in female patients undergoing middle ear surgery. A prospective, randomized, double-blind, placebo-controlled study in 80 female patients [mean age 32.6 years], undergoing middle ear surgery with general anesthesia at Ohud Hospital, Madina, Kingdom of Saudi Arabia from May 2007 to May 2008. Patients were classified into 4 groups. They received intravenous normal saline [S group], midazolam 0.075 mg/kg [M group], or dexamethasone 10 mg [D group], or a combination of midazolam and dexamethasone [MD group], before the induction of anesthesia. Postoperatively for 24 hours observation and assessment of nausea, vomiting, rescue anti-emetics, and side effects of the study drugs such as headache and drowsiness were carried out. There was a significant difference between the 4 groups. The MD group was the least to develop PONV compared to other groups [p<0.01]. Regarding nausea, there was a non-significant difference between the 4 groups, although the MD group developed the least symptoms among the 4 groups, there were no significant differences in pain intensity and side effects such as, headache, dizziness, and drowsiness between the 4 groups. The combination of midazolam 0.075 mg/kg and dexamethasone 10 mg intravenously is better than either drug alone in reducing the incidence of PONV in female patients after middle ear surgery
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Placebos
/
Postoperative Complications
/
Vomiting
/
Midazolam
/
Dexamethasone
/
Random Allocation
/
Double-Blind Method
/
Prospective Studies
/
Drug Therapy, Combination
/
Ear, Middle
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
Language:
English
Journal:
Saudi Med. J.
Year:
2009
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