Antiulcer activity of allium sativum bulb juice in rats

ABSTRACT

The effect of raw Allium sativum Linn. bulb juice on gastric and duodenal ulcers was evaluated by using different gastric ulcer methods and cysteamine induced duodenal ulcer model in rats. Allium sativum Linn, bulb juice was administered orally at two different doses of 250 mg/kg and 500 mg/kg. Both the doses of garlic juice showed gastric ulcer healing effect in acetic acid induced chronic gastric ulcers, produced gastric antisecretory effect in pylorus-ligated rats and also showed gastric cytoprotective effect in ethanol-induced and indomethacin-induced gastric ulcer. The juice also produced a significant reduction in stress induced gastric ulcers and cysteamine-induced duodenal ulcers. The low dose of the juice [250 mg/kg, p.o.] was more effective compared to the high dose [500 mg/kg, p.o.]. It was concluded that juice of Allium sativum Linn. bulb increases healing of gastric ulcers and prevents the development of experimentally induced gastric and duodenal ulcers in rats