Relationship between serum zinc and insulin concentration, insulin resistance and oxidative stress in postmenopausal diabetic women

ABSTRACT

The metabolism of Zine [Zn], an essential nutrient, changes in diabetes. It has been shown that there is a relationship between Zn and both, type 1 or insulin-dependent diabetes mellitus [IDDM] and type 2 or non-insulin-dependent diabetes mellitus [NIDDM]. Increased lipid peroxidation in diabetic patients leads to MDA production. This study aimed to investigate relationships between serum Zn concentration and insulin, insulin resistance and oxidative stress in postmenopausal diabetic women. We studied 45 diabetic women and 45 healthy ones [controls] with BMI 25-30 kg/m2 and age 45-60 y. Fasting blood sugar [FBS], serum zinc, insulin, insulin resistance and MDA were determined in both groups. There were non significant correlations between Zn, insulin [r= -0.06] and insulin resistance [r = -0.027] and MDA [r = -0.09] as well in diabetic group. There were no significant relationships between serum zinc and insulin, insulin resistance and MDA in postmenopausal diabetic women