Topiramate-induced angle closure with acute myopia, macular striae

ABSTRACT

Topiramate is a sulfamate-substituted monosaccharide used is the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy [UBM] clinches the diagnosis after ruling out other causes of shallow tomography anterior chamber. Previous studies have not demonstrated internal limiting membrane folds presenting as macular striae. We report a case of topiramate-induced acute myopia with angle closure and macular striae in a young adult. This is the report wherein striae formation after low doses of topiramate and their resolution have been documented by Optical Coherence Tomography [OCT]