Effects of sphere size, polymer to drug ratio and plasticizer concentration on the release of theophylline from ethylcellulose microspheres
SPJ-Saudi Pharmaceutical Journal. 2007; 15 (3-4): 213-217
in English, Arabic
| IMEMR
| ID: emr-93569
ABSTRACT
Theophylline sustained release microspheres were prepared by applying the non-solvent addition method. The in-vitro release of the drug from the prepared microspheres of different size ranges [= 300, 300-600, 600-800, 800-1000 and 1000-1250 micro m] was studied. The effects of different ethylcellulose theophylline ratios [12, 11 and 21] and different plasticizer [diethylphthalate] concentrations [10, 20 and 30% v/w] on theopylline release were also investigated. At different ethylcellulose theophylline ratios [11, 21 and 12], the release of the drug decreased significantly when the polymer content was increased and the drug loading was decreased. Also, the release was significantly decreased [P<0.05] with increasing plasticizer concentration from 10 to 30%, with no significant difference between un-plasticized and 10% plasticizer
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Particle Size
/
Plasticizers
/
Kinetics
/
Cellulose
/
Delayed-Action Preparations
/
Microspheres
Language:
Arabic
/
English
Journal:
Saudi Pharm. J.
Year:
2007
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