Serum level of heart-type fatty acid-binding protein in patients with chronic renal failure

ABSTRACT

Heart-type fatty acid binding-protein [H-FABP] has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction [AMI]. The effect of kidney diseases on the renal handling of H-FABP has not yet been fully evaluated. The aim of this study was to compare the effect of renal failure on the level of H-FABP and cardiac troponin [cTnT] concentrations. The study population was a small group of 16 patients with renal failure [6 females, 10 males aged 30-70 years] on routine regular haemodialysis or peritoneal dialysis. Results: The mean +/- SD of serum urea and creatinine concentration in this group of patients was 19 +/- 9.6 mmol/L and 531.3 +/- 231.2 mmol/L respectively. H-FABP was increased in all 16 patients [81 +/- 53.3 micro g/L]. The cTnT was increased patients [50%], patients [31.3%], and patient [6%]. The diagnostic efficiency of H-FABP and cTnT for the diagnosis of AMI in the presence of renal failure may be limited and such patients may have high levels even in the absence of AMI