Selective potentiometric determination of meloxicam in pharmaceutical preparations and biological fluids by using polymeric membrane electrode

ABSTRACT

The construction and electrochemical response characteristics of polymeric membrane sensor was investigated for potentiometric determination of meloxicam. The construction of the sensor was based on the incorporation of meloxicam-phosphomolybdate ion-pair in a poly [vinyl chloride] matrix. Linear response over the concentration range of 10[-5]-10[-2] M with anionic slope 55.42 mV per concentration decade. The direct potentiometric determination of meloxicam in pure forms using meloxicam-phosphomolybdate sensor gave average recovery of 99.83 +/- 0.7. The results obtained by the proposed procedure were statistically analyzed and compared with those obtained by using the reported method. The proposed sensor was also applied successfully to the determination of the drug in pharmaceutical preparations and biological fluids. The presence of tablet's excipients did not interfere with the determination of the drug or with the accuracy precision of the proposed method: