Differentiation of Fanconi and aplastic anemia using chromosomal breakage test in Southern Iran

ABSTRACT

Fanconi anemia [FA] is a chromosomal breakage disorder characterized by familial aplastic anemia [AA], various congenital anomalies, and a characteristic chromosomal response to clastogenic stress. In this study, chromosome breakage test was performed for 38 patients suspected of having FA and age-matched controls. According to the results, ten patients were considered as FA cases and 15 patients with no chromosomal breaks were considered as AA. Differentiation of FA from AA is very important because the primary treatment is different. This test should be done in every primary presentation of AA