Effect of uraemia and uraemic toxins on oxygen and glucose uptake of rat diaphragm

ABSTRACT

Uraemia and uraemic toxins [urea, uric acid. creatinine, phenol, dimethylamine, trimethylamine, ethanolamine, serotonin, ammonia, 5-hydroxyindol acetic acid and guanidinosuccinic acid] in concentrations comparable to those found in clinical uraemia were found to have an effect on glucose and oxygen uptake of rat diaphragm. This may explain the diminished peripheral utilization of glucose recorded in uraemic patients. The mechanisms of this effect of toxins were discussed