Microbial contamination of certain non-sterile pharmaceutical raw materials II: Contamination with bacteria of potential health hazard

ABSTRACT

A total of 119 pharmaceutical raw material samples from chemical, animal, plant, or other origin were examined for the presence of bacteria of potential health hazard. Of 71 batches of raw materials of chemical origin 12, 2, 1, 5, 5, 6, 1, 4 and 2 batches were contaminated with Sraphylococeus aureus, Micrococcus pp., E. coil, Enterobacter spp., Citrobacter spp., Proteus spp., Salmonella spp., Shigello spp. and Ps. aeruginosa, respectively. Of 7 batches of raw materials of animal origin 2 batches were contaminated with S. aureus, 2 batches were contaminated with Enterobacter spp. and one batch was contaminated with Citrobacter spp. Of ?2 batches of raw materials of plant origin 3, 2, 1, l, 4, 1, 1 and 1 batches were contaminated with S. aureus, Micrococcus spp., E. coli, Enterobacter spp., Citrobacter spp., Shigella spp., Salmonella and Ps. aeruginosa,, respectively. Of nine batches of miscellaneous raw materials one batch was contaminated with Micracoccus spp. and Proteus spp., one batch was conteaminated with Shigella spp. and Ps, aeruginosa one batch was contaminated with S. eoielermidis, Citrobacter spp., and Ps. aeruginosa, one batch was contaminated with Micrococcus spp., Citrobacter spp., Proteus spp, and E. coli, and one batch was contaminated with S. aureus, Enterobacter spp., Citrobacter spp., Prote is sp. and Ps. aeruginosa. The remaining batches were not contaminated with any of the above mentioned objectionable microorganisms