Effect of lynestrenol and mestranol on serum trace metals [copper-zinc-iron] experimental and clinical observation

ABSTRACT

1- The effect of the two synthetic steroid hormones lynestrenol and mestranol on serum copper, zinc and iron was investigated in female rats and in women. 2. There was a rise of serum copper with mestranol and a decrease in its level with lynestrenol. 3. Serum copper rises with the combination of the two hormones in Lyndiol I. This rise was progressive with the duration of therapy. 4. Serum zinc decreases with Lyndiol both in the pre-and post-menstrual period under Lyndiol I medication. In rats, serum iron rises with mestranol. The relation between serum copper and zinc can be used as a test for the selection of cases or discondinuation of treatment with oral pill, especially in rural areas with endemic bilharziasis