effect of sulphonylureas on total HDL cholesterol and subfractions HDL2C and HDL3C in type II diabetic patients

ABSTRACT

The study was aimed at evaluating the effects of sulphonyhireas on senlni HDL-cholesterol and its subJracdials ill type diabetes mellitus. Sixty three non-obese, newly diagnosed diabetic patients with a short history of disease were studied before and after treatment with sulphaiyhireas for a period of 6 months. We observed highly significant increases in total HDL and HDL-cholesterol after therapy. The HDL3 cholesterol did not change after therapy in the majority of patients and post-therapy rise of total HDL- cholesterol was almost entirely due to a rise in HDL2 cholestrol. Thus, we may conclude that HDL2 cholesterol is more important than HDL-cholesterol in the causation of atherosclerosis. The HDL2 cholesterol levels may predict the development of coronary atherosclerosis