Spectrophotometric method for the determination of metoclopramide

ABSTRACT

A simple and rapid spectrophotometric assay for the determination of metoclopramide hydrochloride in pure and dosage forms has been developed. It is based on the reaction between metoclopramide and 3-methyl-2-benzothiazolone hydrazone in the presence of ferric chloride to give a coloured product with a maximum absorbance at 556 nm. The results obtained are reproducible with a coefficient of variation less than 2% and in a good agreement with the official method. The proposed method is also applicable to urine samples