Histology of upper gastrointestinal lesions in chronic renal failure [CRF] patients

ABSTRACT

One hundred and sixty-eight endoscopic biopsies from the oesophagus, stomach and duodenum in patients with chronic renal failure were examined under light microscope for histologic changes. Patients with histologic alterations were picked up in 81% cases compared to 44.6% on endoscopy alone. Both on endoscopy and on histology, stomach was the commonest site involved followed by duodenum and oesophagus. Oesophagitis was seen in 45% of the cases, reflux oesophagitis constituted the majority of these. In stomach, but not in duodenum, 20% cases showed helicobacter like organisms whereas in duodenum blocked glands were seen in 40% of the biopsies. The results were compared in the normal endoscnpic biopsies obtained from G. I. clinic and these served as controls. The correlation between histology and endoscopy was poor when no lesion was detected on endoscopy