Seasonal variations in the urinary excretion of various metabolites

ABSTRACT

Seasonal variations in urine output and urinary concentration of various metabolites along with fluid intake and intake pattern have been studied in a group of 8 healthy adult individuals. Results have confirmed the reduced fluid intake by all subjects even in hot summer months. This lower fluid intake consequently resulted in reduced urine output, creatinine clearance and increased blood osmolality. The effects are more pronounced and reach a degree of high significance in the summer months. The effect on blood chemistry are similar i.e. the plasma concentration of calcium, phosphorus, uric acid, urea and electrolytes increase constantly from winter to summer months. It is concluded that although normal kidneys are excreting the waste products of metabolism effectively, however, they have to deal with supersaturated blood leading to reduced renal function