Cadmium induced nephrotoxicity

ABSTRACT

Humans are exposed to Cadmium through environmental pollution, industries, food contamination and cigarette smoking and is a sort of cumulative poison especially in kidneys, where it is nephrotoxic. Calcium has been reported to modify cadmium binding to its proximal brush border membrane receptors. In this study, adult spraguedawly rats were fed identical diet, treated with cadmium 1.0 mg, 0.5mg and O. lmg/Kg body weight twice a day for tweleve weeks. Other groups were treated similarly with cadmium and calcium carbonate orally. There was severe renal parenchymal damage in cadmium treated groups than the groups which received both cadmium and calcium carbonate orally