Some hematological and haemostatic aspects in Egyptian patients with brucellosis

ABSTRACT

Haematologic and some haemostatic parameters were investigated in 38 Egyptian patients with brucellosis and 30 normal healthy subjects. The cases were diagnosed by blood culture and the brucella organisms were completely disappeared after treatment by2 weeks. Pretreatment results of haematologic investigations showed very highly significant decrease [P<0.001] in Hb concentration [gm/dl], RBCs count [Cram 3], blood indices [PCV and MCHC, total leucocytic count [Cmm 3], polymorphs% T and eosinophile%. with very highly significant increase [P<0.001] in monocytes% and erythrocyte sedimentation rate [ESR]. Two weeks after therapy, a highly significant decrease [Z> 2.58] was present in the percent of anaemia, leucopenia, thrornbocytopeniu, monocytosis and increase of ESR in brucella group compared to pre-treatment cases. The evaluated haemostatie function tests showed significant changes towards bleeding tendency [platelet count, platelet aggregation and fibrinogen showed a highly significant decrease [P<0.01] while prothrombin time and APTT were Significantly prolonged [p< 0.01] in brucella group. Also, a significant prolongation [P < 0.05] in bleeding time has been found in the same group. The haemostatic ahnormalities were improved after two weeks of treatment [platelet count, platelet aggregation and fibrinogen showed a significant difference [P< 0.05], while prothrombin time and APTT showed a highly significant decrease [P<0.001] compared to pre-treatment values. Also, a significant decrease in bleeding time has been observed in brucella group