spectrum of chronic disease and the morphology of chronic hepatitis B and C

ABSTRACT

To determine the spectrum of chronic liver disease and to study the morphology of chronic Viral Hepatitis B and C, a total of 120 patients with a clinico-pathological of Chronic liver disease were studied. Out of these equal number of seropositive cases for hepatitis B and C [n=60 each] the histopathology revealed that; respectively 25% and 6.6% had Chronic Persistent Hepatitis; 13.3% and 10% had Chronic Lobular Hepatitis; 38.3% and 60% had Chronic Active Hepatitis; 15% and 16.6% had Cirrhosis and 8.3% and 6.6 had Hepato-cellular carcinoma. The patients with Chronic Hepatitis C showed more portal lymphoid aggregates [82.6% versus 26%], Steatosis [76% versus 32%], Mallory body like material in hepatocytes [30.4% in HCV positive cases only], and activation of sinusoidal inflammatory cells [58.6% versus 21.7%]. Whereas the patients with Chronic Hepatitis B showed more of ground glass hepatocytes [54% versus 2.1%] multinucleated giant cells [50% of HBV positive cases only], and liver cell dysplasia [26% versus 15.2%]. In conclusion some these histological parameters were useful in diagnosis of chronic liver disease due to hepatitis B and C viruses