Alarming state of emerging resistance in salmonella typhi to conventional antityphoid drugs in the Kharian region

ABSTRACT

Enteric fever remains and important cause of mortality and morbidity in the under developed and the developing countries of the world. Once an illness of the hot weather, it is now endemic in Pakistan throughout the year. After the emergence of chloramphenicol [CAP] resistant Samonella typhi in Pakistan, this trend has been of the rise. In the Kharian region, about 93% of S. typhi are found resistant to conventional antityphoids [CAP, ampicillin and cotrimoxazole]. However, all the isolates remained susceptible to fluoroquinolones [ciprofloxacin and ofloxacin] and third generation cephalosporin [ceftriaxone] except S. paratyphi A which was uniformly sensitive to all the conventional antityphoids, fluoroquinolones and third generation cephalosporins