Safety and efficacy of ciprofloxacin in the treatment of complicated urinary tract infections

ABSTRACT

One hundred patients with complicated urinary tract infection with significant colony counts were treated. The most common organism was Escherichia coli [86%], Pseundomonas aeruginosa [8%], Klebsiella [4%] and mixed infection with Escherichia coli and Proteus mirabilis [2%]. Most of the patients started showing improvement within 48 to 72 hours and complete recovery was achieved with 7 to 10 days with Ciprofloxacin 250 mg twice daily. A cure rate of 98% was achieved. Adverse effects were insignificant. There were no significant changes in the renal and liver function tests after the therapy. All the patients were followed up for a period of six months. Most of the patients with anatomical structural deformities were later on treated surgically. Since complicated UTI is a serious problem the safety and efficacy of only one drug with newer fluoroquinolones was studied